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KMID : 0370220160600040200
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Yakhak Hoeji
2016 Volume.60 No. 4 p.200 ~ p.206
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Behavioral Characteristics of GRIN3A-overexpressing Transgenic Mice
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Woo Tae-Seon
Cheong Jae-Hoon
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Abstract
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N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels that play a significant role in synaptic plasticity, learning, memory, and other behaviors. NMDARs are composed of various subunits and display unique properties depending on their subunit composition. The GluN3A subunit is thought to suppress NMDAR activity, however
its exact function has not been well studied. Thus, we designed a transgenic mice overexpressing GRIN3A to assess the
role of this gene on various behaviors. GRIN3A-overexpressing mice were subjected to an array of behavioral experiments
including locomotor activity test, rota-rod test, elevated plus-maze (EPM) test, and Y-maze test. GRIN3A-overexpressing
mice displayed hypoactivity but no effects on the rota-rod test, EPM test and Y-maze test. The GRIN3A-overexpressing
mice that we have created can be utilized in elucidating the role of the GRIN3A gene and its product, the GluN3A subunit
of NMDARs, on various behaviors associated with neuropsychiatric disorders, such as ADHD, and in finding possible therapeutic targets for these disorders.
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KEYWORD
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GRIN3A, hypoactivity, GluN3A, NMDA
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